When building Python 3.7.2 using pyenv on MacOS, it will use `--with-openssl` to configure OpenSSL. With that option, the compiler options for OpenSSL will be passed via `OPENSSL_*` variables, rather than normal compiler flags (e.g. `OPENSSL_LDFLAGS` vs. `LDFLAGS`). When compiling an extension, these flags will not be propagated by `distutils`, and so an extension that depends on OpenSSL fails to compile.

I'm not sure what the expected behavior here is. Should the package handle this by querying `sysconfig` directly in `setup.py`? Or should this be handled automatically by `distutils`?

Specifically, I ran into this issue when trying to install `mysqlclient-python` (https://github.com/PyMySQL/mysqlclient-python).

'--with-openssl' purpose is to override the OpenSSL location for Python's internal _ssl and _hashlib module. It is not designed to interfere with 3rd party extensions that are built with distutils or setuptools.

It is the decision of a 3rd party package how it wants to handle these extra flags -- or if it is able to use them at all. In case of PyMySQL you must use the same shared libraries as libmysqlclient. You cannot use a  different OpenSSL ABIs, APIs, or shared libraries for PyMySQL and libmysqlclient.

Thanks for the response, that clarifies it! In that case this issue is invalid.