When running doctest.testfile on a Linux machine, testing a txt file 
saved on a Windows machine, doctest raised a SyntaxError exception for 
each Windows newline in the txt file. On examining the code in the 
_load_testfile function, it looks to me like there are actually two 
issues:

(1) When there is no package keyword argument given, or the package 
argument points to a package without a __loader__.get_data method, the 
txt file data is retrieved by calling open(filename).read(); this is 
the code path that my Windows-saved file triggered. However, since the 
default file mode for open is 'r', not 'rU', there is no universal 
newline conversion done on the file data. This was the issue I 
initially observed.

(2) When there is a package.__loader__.get_data method found, that 
method reads the data (using file mode 'rb'), and then newline 
conversion is performed by this line:

return file_contents.replace(os.linesep, '\n')

This does not seem to match what universal newline conversion does; 
that is supposed to convert both '\r\n' and '\r' to '\n', but running 
on Linux, os.linesep is '\n', so the replace operation in the current 
code is a no-op, even if the txt file was saved with Windows or Mac 
newlines. It seems to me that the correct operation would be:

for linesep in ('\r\n', '\r'):
   file_contents = file_contents.replace(linesep, '\n')

I have attached a diff against the current svn trunk showing my 
suggested fix for both of the above issues.

Peter Donis