Running this on Mac OS X:
$ ./configure --with-pydebug --enable-framework
$ make

I get this:
(...)
ar cr libpython3.0.a Modules/config.o Modules/getpath.o Modules/main.o 
Modules/gcmodule.o 
ar cr libpython3.0.a Modules/threadmodule.o  Modules/signalmodule.o  
Modules/posixmodule.o  Modules/errnomodule.o  Modules/pwdmodule.o  Modules/_sre.o  
Modules/_codecsmodule.o  Modules/_fileio.o  Modules/zipimport.o  
Modules/symtablemodule.o  Modules/xxsubtype.o
ranlib libpython3.0.a
/usr/bin/install -c -d -m 755 Python.framework/Versions/3.0
if test ""; then \
        gcc -o Python.framework/Versions/3.0/Python -arch i386 -arch ppc -dynamiclib 
\
                -isysroot "" \
                -all_load libpython3.0.a -Wl,-single_module \
                -install_name 
/Library/Frameworks/Python.framework/Versions/3.0/Python \
                -compatibility_version 3.0 \
                -current_version 3.0; \
        else \
        /usr/bin/libtool -o Python.framework/Versions/3.0/Python -dynamic  
libpython3.0.a \
                 -lSystem -lSystemStubs -arch_only i386 -install_name 
/Library/Frameworks/Python.framework/Versions/3.0/Python -compatibility_version 3.0 -
current_version 3.0 ;\
fi
ld: Undefined symbols:
___eprintf
/usr/bin/libtool: internal link edit command failed
make: *** [Python.framework/Versions/3.0/Python] Error 1

If using only --with-pydebug it works fine.