'urlencode()' is a TypeError as a query (dict) is needed.  The claim is that '/?' in a key are encoded but should not be.  I verified the encoding in 3.10.

>>> urlencode({'/?link': 'pubmed'})  
'%2F%3Flink=pubmed'

https://docs.python.org/3/library/urllib.parse.html#urllib.parse.urlencode
https://docs.python.org/3/library/urllib.parse.html#urllib.parse.quote
and the following entry from 'quote_plus' say that by default, quote_via is quote_plus and the latter quotes '/' and '?'.  So the bug report as stated is not valid.
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They also say that passing 'quote_via=quote' should suppress quoting of '/', because it defaults to 'safe='/', but it does not.

>>> urlencode({'/?link': 'pubmed'}, quote_via=quote)
'%2F%3Flink=pubmed'

So either the doc should be changed in 3 places, or the default safe for quote should be '/' as documented.
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Anh, use safe='/?' to get what you want.

>>> urlencode({'/?link': 'pubmed'}, quote_via=quote, safe='/?')
'/?link=pubmed'