Part of the problem here is that most keys in the result of sysconfig.get_config_vars() are copied as-is from the CPython Makefile and pyconfig.h header file.

The keys copied from the Makefile are in a lot of cases not useful for users of python because they contain values that are only useful while building CPython itself. 

Without knowing your use case it is hard to point you to a better solution, but as Ned writes in general just follow the instructions from the extending and embedding documentation.