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I looked into this a bit further, and noticed the following:

The modules bz2, cStringIO and mmap all use plain integers
to represent file offsets given to or returned by seek(),
tell() and truncate().

They should be corrected to use a 64-bit type when having
large file support. fileobject.c defines an own type for
that, Py_off_t, which should be shared among the other modules.

Conditional compile is needed since different
macros/functions must be used.