>I don't know the physical disk type on Windows. Can you read and write from such "file" type?

Yes this "files" can be readed and writed (with restriction - size of the data must be a multiple of the sector size)

in python 3.4.3 open,read,write,seek - works fine (with raw usb disk)
for python 3.5 as workaround I replaced these functions to os.xxxx

>2) get the block size
st_blksize is not implemented under windows