Serhiy,
52 usec/loop doesn't seem like much overhead. This is not 52 usec per row fetched, but just 52 usec per cursor.execute(). An example where >1 row is fetched for each cursor would show this more clearly.

The advantage of namedtuple is that it's a very well-known interface to most Python programmers. Other db-api modules have taken a similar approach; psycopg2 has a dict-like cursor similar to Row, but has added NameTupleCursor in recent versions. (http://initd.org/psycopg/docs/extras.html#namedtuple-cursor)