Although mainly focussed on MinGW, I've begun adding Darwin cross support. I've also built Darwin cross compilers. The latest Linux version can be found at:

http://mingw-and-ndk.googlecode.com/files/multiarch-darwin11-cctools127.2-gcc42-5666.3-llvmgcc42-2336.1-Linux-120531.tar.xz

Here's a run-down of what's in the patch:

configure.ac:
 Set MACHDEP=darwin when using darwin-cross compilers.
 Set DELIM to ; for MACHDEP=win.
 Switch from PC/getpathp.c to Modules/getpath.c for MinGW build.
  This gives us a posix like layout as needed by autotools projects
  such as GDB.
 Add MSYSVPATH as an env. var to configure (used in getpath.c):
  MSYS make uses a 'virtual' VPATH, but getpath.c uses
  GetModuleFileNameW (replacing \ with /). This allows the user to
  define the 'actual 'real' value. Note, it should contain / not \,
  (i.e. use ecactly what is printed by "pwd -W")
 Fixes to build with MinGW64 for REPARSE_DATA_BUFFER (needs defining)

Include/fileutils.h:
 Define Py_wstat for MinGW/MinGW64.

Include/osdefs.h:
 Define SEP to / and ALTSEP to \ for MinGW.

cygwinccompiler.py:
 Fix RE_VERSION in for handling MinGW64 compiler versioning.
 Ask gcc where ld is instead of requiring it to be passed in os.environ
 
plat-generic/regen:
 Allow passing in the CC so sysroots can be determined from -print-search-dirs
 If this CC passing is detected, use $CCINSTALL/include/stddef.h as netinet/in.h doesn't come with MinGW.

Moules/faulthandler.c:
 Avoid _set_abort_behavior on MinGW64 as it's broken.

Modules/getpath.c:
 Add support for MinGW.

Modules/socketmodule.c:
 Change case (to lower) of #include <MSTcpIP.h> for MinGW/MinGW64 cross.

Parser/metagrammar.c:
 Rename _PyParser_Grammar to _PyParser_MetaGrammar to avoid multiply defined symbols.

Python/pythonrun.c:
 Translate ALTSEP (\) to SEP (/) in Py_SetProgramName

setup.py:
 Add 'msi','cabinet','rpcrt4' as libs to link against for _msi module.
 Fix an error with self.get_platform() no longer being defined (changed to host_platform)

Best regards,

Ray Donnelly.