I rather doubt that there will be any problem with Python invoked through a wrapper.
Gentoo's python-wrapper isn't used when target executable (e.g. /usr/bin/python3.1) is directly called.  A side effect of python-wrapper is that sys.executable is the target executable:
$ readlink /usr/bin/python
python-wrapper
$ /usr/bin/python -c 'import sys; print(sys.executable)'
/usr/bin/python3.1
$ /usr/bin/python-wrapper -c 'import sys; print(sys.executable)'
/usr/bin/python3.1
$ sh -c "exec -a '' /usr/bin/python -c 'import sys; print(sys.executable)'"
/usr/bin/python3.1
$ sh -c "exec -a '' /usr/bin/python3.1 -c 'import sys; print(sys.executable)'"
/usr/bin/python

If there is a patch, then I can test it.