https://bugs.python.org/issue43466 added a way to set OpenSSL rpath explicitly via --with-openssl-rpath=DIR, which is cool!  However, the current configuration code checks for the presence of the specified directory eagerly, which breaks setups where both OpenSSL and Python are being built at the same time, but not necessarily installed to the runtime location (think omnibus debs).  Unless there's a good reason why an eager check is needed, I think it should be dropped to ease packaging.