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I don't understand the rationale for
Modules/expat/osxconfig.h. I thought there was some magic to
make Python.h's WORDS_BIGENDIAN always correct. If so,
BYTEORDER wouldn't be needed at all anymore.

In Makefile.pre.in, the -install-name option seems to imply
-enable-framework. If this is indeed a hard dependency,
configuring with universal-sdk, yet without framework should
make configure abort. If it's not a hard dependency, the
linker command line should be corrected for the case of
--disable-framework.

Minor issues:
- avoid empty statements; reverse the if test
"${enable_universalsdk}"; test
- shouldn't the -current-version include the micro release?