I close the issue. While this issue is not fully fixed, it's a milestone of my "stable ABI" goal. I prefer to address remaining issues in new separted issues.

This issues is not fully fixed, there are are still a 4 macros which access directly PyTypeObject members:

* PySequence_ITEM()
* _PyObject_SIZE()
* _PyObject_VAR_SIZE()
* PyType_HasFeature() (if Py_LIMITED_API is not defined)

PySequence_ITEM() and PyType_HasFeature() are important for performance, I prefer to have a PEP before changing these two functions.

_PyObject_SIZE() and _PyObject_VAR_SIZE() should be made public with a better name like PyObject_SizeOf() and PyVarObject_SizeOf(). But I prefer to do that in a separated issue.

IMO it would be interesting to merge the PyHeapTypeObject structure into the PyTypeObject structure:
https://bugs.python.org/issue46433#msg411167

And make the PyTypeObject opaque: deprecate static types and promote the usage of heap types in C extensions. That's a big project which may be splitted into multiple issues and the final change may need its own PEP.