Actually, the CRLF + space can be injected via percent encoding, so just dealing with literal CRLFs and spaces wouldn’t be enough. You would have to validate the hostname after it is decoded.

urlopen("http://127.0.0.1%0D%0A%20SLAVEOF . . . :6379/")

>>> pprint(conn.recv(300).splitlines(keepends=True))
[b'GET / HTTP/1.1\r\n',
 b'Accept-Encoding: identity\r\n',
 b'Host: 127.0.0.1\r\n',
 b' SLAVEOF . . . :6379\r\n',
 b'Connection: close\r\n',
 b'User-Agent: Python-urllib/2.7\r\n',
 b'\r\n']