I submitted a patch years ago that addressses the ''x,y = 1, 2' case:
http://bugs.python.org/issue10648 & it was not met with enthusiasm

2016-04-10 5:08 GMT+00:00 Alexander Marshalov <report@bugs.python.org>:

>
> Alexander Marshalov added the comment:
>
> Hi all, this is my first patch to Python.
> I'm interested in the performance of python code, I even worked on the
> development of the static optimizer based on modifications of the AST.
> I had a few ideas for improving peepholer (for example, the expression "x,
> y = 1, 2" according to my benchmarks is about 7-11% slower than the
> expression "x = 1; y = 2", this can be fixed by using a peepholer), but I
> already understood that it is not necessary to do it.
> Thanks for the clarification, I will continue to work towards
> AST-optimizations.
>
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