The following program should print "0xdead" but instead prints "0x0".  This came from the following stackoverflow question:
http://stackoverflow.com/questions/3824617/python-structure-always-stuck-at-0-no-matter-what-value-you-assign-to-it

import ctypes
class Blah(ctypes.Structure):
    _fields_ = [("a", ctypes.c_uint64, 64),
                ("b", ctypes.c_uint16, 16),
                ("c", ctypes.c_uint8, 8),
                ("d", ctypes.c_uint8, 8)]

x = Blah(0xDEAD,0xBEEF,0x44,0x12)
print(hex(x.a))

An endian issue? (i.e. on OS X, it works on ppc but not Intel)
A slightly more detailed test case:

$ more test_ctypes.py
import ctypes
class Blah2(ctypes.Structure):
    _fields_ = [("x", ctypes.c_uint64, 64),
                ("y", ctypes.c_uint64)]
val = 0x0123456789ABCDEF
x = Blah2(val, val)
print(Blah2.x)
print(hex(x.x))
print(Blah2.y)
print(hex(x.y))
$ arch -i386 python2.7 test_ctypes.py
<Field type=c_ulonglong, ofs=0:0, bits=64>
0x0L
<Field type=c_ulonglong, ofs=8, size=8>
0x123456789abcdefL
$ arch -x86_64 python2.7 test_ctypes.py
<Field type=c_ulong, ofs=0:0, bits=64>
0x0L
<Field type=c_ulong, ofs=8, size=8>
0x123456789abcdefL
$ arch -ppc python2.7 test_ctypes.py
<Field type=c_ulonglong, ofs=0:0, bits=64>
0x123456789abcdefL
<Field type=c_ulonglong, ofs=8, size=8>
0x123456789abcdefL

Could be.  FWIW, I had tested and observed the problem on a 32-bit Intel Windows box and 64-bit Intel Linux box.

I think this issue is duplicate of #6493.