Python 2.7.9 (default, Apr  2 2015, 15:33:21) 
[GCC 4.9.2] on linux2
Type "help", "copyright", "credits" or "license" for more information.
>>> (2,)==(2)
False
>>> (2,3,)==(2,3)
True
>>> (2,3)==(2,3,)
True
>>> s=(2,)
>>> s2=(2)
>>> s==s2
False
>>>

Refer to section 6.2.3, parenthesized forms:

https://docs.python.org/3/reference/expressions.html#parenthesized-forms

    if the list contains at least one comma, it yields a tuple;
    otherwise, it yields the single expression that makes up the
    expression list.

So (2) is an int, while (2,) is a tuple that contains an int.

    The exception is the empty tuple, for which parentheses are
    required — allowing unparenthesized “nothing” in 
    expressions would cause ambiguities and allow common typos
    to pass uncaught.

Thus () is an empty tuple. Note also that section 6.13 states the following regarding a trailing comma:

    The trailing comma is required only to create a single 
    tuple (a.k.a. a singleton); it is optional in all other 
    cases.