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I guess I'm not making myself very clear. Let me try again...

I have a library that completely encapsulates all use of
Python.h from my clients. I need to be able to debug this
library by compiling it with DEBUG. I do not want to use
the debug Python library. Unfortunately, just compiling
the Python headers with DEBUG seems to change the object
layout and require the use of the debug library.

BTW, the sys.path values include my PYTHONPATH values when
I link non-debug, and they are the default relative path
values when I link with debug. I know the code looks like
it doesn't ignore PYTHONPATH (I've looked through
getpathp.c too) but something is screwing up sys.path.