The body font size is good now, but now lot of elements are too big. 
Here are list of issues in typical pages related to the font change:

Module page: (e.g. http://docs.python.org/dev/library/bisect.html)

- content headings
- the bread-crumbs navigation flow to out of its div when the using 
narrow window or huge font in the browser
- previous|next... links in the header
- headings in the sidebar are huge
- text in the sidebar can be smaller then the body text
- copyright line - can by tiny

Main page (http://docs.python.org/dev/index.html):

- The main titles (e.g. What's new in ...) are huge - 100-120% should be 
fine. (CSS class biglink)
- The links description may be smaller then the regular body text