The link https://github.com/facebookincubator/cinder/blob/cinder/3.8/Python/ceval.c#L6617 points to something that I wouldn't associate with the subject. @Dino, could you provide a new link (preferably a permalink)?

FWIW rather than dynamically checking what the next opcode is, maybe we could use a super-instruction for CALL + GET_AWAITABLE? (Understanding that there are a bunch of different CALL opcodes.)

The gather code you link to is all in C. Is rewriting gather in C the only way to benefit from this speedup? (I guess you could just add your gather impl to the existing _asynciomodule.c, in the same or a separate PR.)