_destructor in connection.c in Python 3.10+ now calls `PyGILState_Ensure()`, this is a problem because if the destructor is being called while the thread is being torn down it will cause an unbalanced/erroneous call to "PyEval_RestoreThread" in PyGILState_Ensure which will eventually trigger a Fatal Python Error. A perfect repro has been attached, should be run on Linux.

My recommended fix is to call sqlite3_close() within Py_BEGIN_ALLOW_THREADS/Py_END_ALLOW_THREADS, and manually Py_DECREF all connection-related functions afterward.