Ok, I reproduced the issue. I wrote PR 30929 to fix it.

The issue only occurs when cross-compiling Python with GCC and a German locale. I can reproduce the issue on Fedora 35:

$ LC_ALL=de_DE gcc -E -v
Es werden eingebaute Spezifikationen verwendet.
COLLECT_GCC=gcc
OFFLOAD_TARGET_NAMES=nvptx-none
OFFLOAD_TARGET_DEFAULT=1
Ziel: x86_64-redhat-linux
Konfiguriert mit: ../configure --enable-bootstrap --enable-languages=c,c++,fortran,objc,obj-c++,ada,go,d,lto --prefix=/usr --mandir=/usr/share/man --infodir=/usr/share/info --with-bugurl=http://bugzilla.redhat.com/bugzilla --enable-shared --enable-threads=posix --enable-checking=release --enable-multilib --with-system-zlib --enable-__cxa_atexit --disable-libunwind-exceptions --enable-gnu-unique-object --enable-linker-build-id --with-gcc-major-version-only --with-linker-hash-style=gnu --enable-plugin --enable-initfini-array --with-isl=/builddir/build/BUILD/gcc-11.2.1-20211203/obj-x86_64-redhat-linux/isl-install --enable-offload-targets=nvptx-none --without-cuda-driver --enable-gnu-indirect-function --enable-cet --with-tune=generic --with-arch_32=i686 --build=x86_64-redhat-linux --with-build-config=bootstrap-lto --enable-link-serialization=1
Thread-Modell: posix
Unterst�tzte LTO-Kompressionsalgorithmen: zlib zstd
gcc-Version 11.2.1 20211203 (Red Hat 11.2.1-7) (GCC) 

The last line starts with "gcc-Version 11.2.1". Whereas the last line starts with "gcc version 11.2.1" with the C locale:

$ LC_ALL=C gcc -E -v
Using built-in specs.
COLLECT_GCC=gcc
OFFLOAD_TARGET_NAMES=nvptx-none
OFFLOAD_TARGET_DEFAULT=1
Target: x86_64-redhat-linux
Configured with: ../configure --enable-bootstrap --enable-languages=c,c++,fortran,objc,obj-c++,ada,go,d,lto --prefix=/usr --mandir=/usr/share/man --infodir=/usr/share/info --with-bugurl=http://bugzilla.redhat.com/bugzilla --enable-shared --enable-threads=posix --enable-checking=release --enable-multilib --with-system-zlib --enable-__cxa_atexit --disable-libunwind-exceptions --enable-gnu-unique-object --enable-linker-build-id --with-gcc-major-version-only --with-linker-hash-style=gnu --enable-plugin --enable-initfini-array --with-isl=/builddir/build/BUILD/gcc-11.2.1-20211203/obj-x86_64-redhat-linux/isl-install --enable-offload-targets=nvptx-none --without-cuda-driver --enable-gnu-indirect-function --enable-cet --with-tune=generic --with-arch_32=i686 --build=x86_64-redhat-linux --with-build-config=bootstrap-lto --enable-link-serialization=1
Thread model: posix
Supported LTO compression algorithms: zlib zstd
gcc version 11.2.1 20211203 (Red Hat 11.2.1-7) (GCC)