Here are the 3 steps to reproduce with minimal pgo training. (vs2019)

1. Download the source archive of PR29565 and extract.
   https://github.com/python/cpython/archive/6a84d61c55f2e543cf5fa84522d8781a795bba33.zip

2. Apply the following patch.

==============================
--- PCbuild/build.bat
+++ PCbuild/build.bat
@@ -66 +66 @@
-set pgo_job=-m test --pgo
+set pgo_job=-c"pass"
--- PCbuild/pyproject.props
+++ PCbuild/pyproject.props
@@ -47,2 +47,3 @@
       <AdditionalOptions>/utf-8 %(AdditionalOptions)</AdditionalOptions>
+      <AdditionalOptions Condition="$(SupportPGO) and $(Configuration) == 'PGUpdate'">/d2inlinelogfull:_PyEval_EvalFrameDefault %(AdditionalOptions)</AdditionalOptions>
     </ClCompile>
==============================

3. Build [Rebuild]

   PCbuild\build --no-tkinter --pgo > build.log [-r]

   According to the inlining section in the log, any function that has one or more conditional expressions got "reject" from inliner.

   > Inlinee for function _PyEval_EvalFrameDefault 
   >  -_Py_EnsureFuncTstateNotNULL (pgo hard reject)
   >  ...
   >  _Py_INCREF (pgu decision)
   >  _Py_INCREF (pgu decision)
   >  -_Py_XDECREF (pgo hard reject)
   >  -_Py_XDECREF (pgo hard reject)
   >  -_Py_DECREF (pgo hard reject)
   >  -_Py_DECREF (pgo hard reject)
   >  ...


Profiling scores can be shown on VS2019 Command Prompt.

   pgomgr PCbuild\amd64\python311.pgd /summary [/detail] > largefile.txt

   * pgomgr.exe (or profile itself) has an issue.
     https://developercommunity.visualstudio.com/t/1560909


Unused opcodes in this training

   ROT_THREE, DUP_TOP_TWO, UNARY_POSITIVE, UNARY_NEGATIVE,
   BINARY_OP_ADD_FLOAT, UNARY_INVERT, BINARY_OP_MULTIPLY_INT,
   BINARY_OP_MULTIPLY_FLOAT, GET_LEN, MATCH_MAPPING, MATCH_SEQUENCE,
   MATCH_KEYS, LOAD_ATTR_SLOT, LOAD_METHOD_CLASS, GET_AITER, GET_ANEXT,
   BEFORE_ASYNC_WITH, END_ASYNC_FOR, STORE_ATTR_SLOT,
   STORE_ATTR_WITH_HINT, GET_YIELD_FROM_ITER, PRINT_EXPR, YIELD_FROM,
   GET_AWAITABLE, LOAD_ASSERTION_ERROR, SETUP_ANNOTATIONS, UNPACK_EX,
   DELETE_ATTR, DELETE_GLOBAL, ROT_N, COPY, DELETE_DEREF,
   LOAD_CLASSDEREF, MATCH_CLASS, SET_UPDATE, DO_TRACING

   I managed to activate inliner experimentally by removing the 36 op-cases from switch and merging/removing many macros.


Static instruction counts of _PyEval_EvalFrameDefault()

   PR29565   : 6882 (down to 4400 with above change)

   PR29482   : 7035
   PR29482~1 : 7742
   3.10.0+   : 3980 (well inlined sharing DISPATCH macro)
   3.10.0    : 5559
   3.10b1    : 5680
   3.10a7    : 4117 (well inlined)