> FTR, this is only a problem if you link with the Apple-supplied system libsqlite3 [...]

Sure, but that should be relatively trivial to detect. AFAIK, the SQLite command line shell seems to be located at the same path every release, so I would guess that also applies for the library.

Alternatively, we could dump the compile options and grep for SQLITE_OMIT_LOAD_EXTENSION, but that implies locating the SQLite command line shell that corresponds to the library that we're using. Probably trickier, but would definitely be useful if/when we add support for the SQLite serialize API, RTree callbacks, etc.