Using INADA-san recipe https://github.com/methane/notes/tree/master/2020/wchar-cache I found the 62 projects on the PyPI top 4000 which contain "PyFPE" pattern:

asyncpg-0.22.0.tar.gz
auditwheel-3.3.1.tar.gz
av-8.0.3.tar.gz
bcolz-1.2.1.tar.gz
BDQuaternions-0.2.15.tar.gz
bx-python-0.8.9.tar.gz
ConfigSpace-0.4.18.tar.gz
Cython-0.29.21.tar.gz
cytoolz-0.11.0.tar.gz
ddtrace-0.46.0.tar.gz
dedupe-hcluster-0.3.8.tar.gz
dependency-injector-4.23.5.tar.gz
fastavro-1.3.2.tar.gz
fastdtw-0.3.4.tar.gz
Fiona-1.8.18.tar.gz
fuzzysearch-0.7.3.tar.gz
fuzzyset-0.0.19.tar.gz
gensim-3.8.3.tar.gz
grpcio-1.35.0.tar.gz
gssapi-1.6.12.tar.gz
hdbscan-0.8.27.tar.gz
hmmlearn-0.2.5.tar.gz
imagecodecs-2021.1.28.tar.gz
implicit-0.4.4.tar.gz
lightfm-1.16.tar.gz
lupa-1.9.tar.gz
lxml-4.6.2.tar.gz
mujoco-py-2.0.2.13.tar.gz
neobolt-1.7.17.tar.gz
orderedset-2.0.3.tar.gz
peewee-3.14.1.tar.gz
Pillow-8.1.0.tar.gz
Pillow-SIMD-7.0.0.post3.tar.gz
pmdarima-1.8.0.tar.gz
pomegranate-0.14.2.tar.gz
pycapnp-1.0.0.tar.gz
pydevd-2.2.0.tar.gz
pygame-2.0.1.tar.gz
pyhacrf-datamade-0.2.5.tar.gz
pyjq-2.5.1.tar.gz
pysam-0.16.0.1.tar.gz
pystan-2.19.1.1.tar.gz
PyWavelets-1.1.1.tar.gz
rasterio-1.2.0.tar.gz
ruptures-1.1.3.tar.gz
s2sphere-0.2.5.tar.gz
scikit-image-0.18.1.tar.gz
scipy-1.6.1.tar.gz
Shapely-1.7.1.tar.gz
simplejson-3.17.2.tar.gz
spacy-3.0.3.tar.gz
statsmodels-0.12.2.tar.gz
tables-3.6.1.tar.gz
Theano-1.0.5.tar.gz
thinc-8.0.1.tar.gz
tinycss-0.4.tar.gz
tslearn-0.5.0.5.tar.gz
uvloop-0.15.1.tar.gz
weighted_levenshtein-0.2.1.tar.gz
wordcloud-1.8.1.tar.gz
wsaccel-0.6.3.tar.gz
wxPython-4.1.1.tar.gz


Example with asyncpg:

$ rg PyFPE
asyncpg/pgproto/pgproto.c
39841:            PyFPE_START_PROTECT("add", return NULL)
39843:            PyFPE_END_PROTECT(result)

asyncpg/protocol/protocol.c
85260:            PyFPE_START_PROTECT("add", return NULL)
85262:            PyFPE_END_PROTECT(result)
85563:            PyFPE_START_PROTECT("subtract", return NULL)
85565:            PyFPE_END_PROTECT(result)
85734:            PyFPE_START_PROTECT("add", return NULL)
85736:            PyFPE_END_PROTECT(result)


So it doesn't sound like a good idea to immediately remove these two macros.