I have repeated the benchmark in the speed.python.org server with CPU isolation + PGO + LTO:

Slower (21):
- xml_etree_iterparse: 127 ms +- 2 ms -> 131 ms +- 2 ms: 1.03x slower (+3%)
- xml_etree_parse: 195 ms +- 1 ms -> 200 ms +- 2 ms: 1.03x slower (+3%)
- pickle_list: 5.62 us +- 0.05 us -> 5.76 us +- 0.06 us: 1.03x slower (+3%)
- pickle: 13.2 us +- 0.1 us -> 13.5 us +- 0.1 us: 1.02x slower (+2%)
- scimark_lu: 185 ms +- 3 ms -> 188 ms +- 5 ms: 1.02x slower (+2%)
- scimark_fft: 427 ms +- 2 ms -> 434 ms +- 2 ms: 1.02x slower (+2%)
- sympy_integrate: 25.0 ms +- 0.2 ms -> 25.3 ms +- 0.2 ms: 1.01x slower (+1%)
- spectral_norm: 166 ms +- 3 ms -> 169 ms +- 1 ms: 1.01x slower (+1%)
- scimark_sor: 246 ms +- 6 ms -> 249 ms +- 4 ms: 1.01x slower (+1%)
- sympy_sum: 203 ms +- 2 ms -> 205 ms +- 2 ms: 1.01x slower (+1%)
- chaos: 138 ms +- 1 ms -> 139 ms +- 1 ms: 1.01x slower (+1%)
- json_loads: 37.2 us +- 1.0 us -> 37.5 us +- 0.3 us: 1.01x slower (+1%)
- xml_etree_process: 91.0 ms +- 1.1 ms -> 91.7 ms +- 1.8 ms: 1.01x slower (+1%)
- sympy_str: 315 ms +- 2 ms -> 317 ms +- 2 ms: 1.01x slower (+1%)
- sqlalchemy_declarative: 210 ms +- 3 ms -> 211 ms +- 3 ms: 1.01x slower (+1%)
- regex_compile: 214 ms +- 1 ms -> 215 ms +- 1 ms: 1.01x slower (+1%)
- regex_dna: 268 ms +- 1 ms -> 270 ms +- 1 ms: 1.01x slower (+1%)
- logging_format: 11.2 us +- 0.1 us -> 11.3 us +- 0.2 us: 1.01x slower (+1%)
- unpickle_pure_python: 392 us +- 4 us -> 394 us +- 4 us: 1.00x slower (+0%)
- sympy_expand: 492 ms +- 2 ms -> 493 ms +- 3 ms: 1.00x slower (+0%)
- pidigits: 236 ms +- 1 ms -> 236 ms +- 1 ms: 1.00x slower (+0%)

Faster (21):
- unpack_sequence: 73.9 ns +- 1.3 ns -> 69.3 ns +- 1.0 ns: 1.07x faster (-6%)
- 2to3: 405 ms +- 2 ms -> 393 ms +- 2 ms: 1.03x faster (-3%)
- float: 146 ms +- 1 ms -> 142 ms +- 2 ms: 1.03x faster (-3%)
- scimark_sparse_mat_mult: 5.46 ms +- 0.02 ms -> 5.34 ms +- 0.06 ms: 1.02x faster (-2%)
- unpickle: 17.1 us +- 0.1 us -> 16.7 us +- 0.2 us: 1.02x faster (-2%)
- regex_effbot: 3.89 ms +- 0.11 ms -> 3.82 ms +- 0.03 ms: 1.02x faster (-2%)
- json_dumps: 15.9 ms +- 0.1 ms -> 15.7 ms +- 0.1 ms: 1.01x faster (-1%)
- python_startup: 12.4 ms +- 0.1 ms -> 12.3 ms +- 0.0 ms: 1.01x faster (-1%)
- go: 320 ms +- 4 ms -> 316 ms +- 3 ms: 1.01x faster (-1%)
- pathlib: 25.4 ms +- 0.4 ms -> 25.1 ms +- 0.3 ms: 1.01x faster (-1%)
- mako: 19.6 ms +- 0.2 ms -> 19.4 ms +- 0.1 ms: 1.01x faster (-1%)
- fannkuch: 598 ms +- 7 ms -> 591 ms +- 4 ms: 1.01x faster (-1%)
- hexiom: 12.2 ms +- 0.2 ms -> 12.1 ms +- 0.1 ms: 1.01x faster (-1%)
- richards: 85.9 ms +- 1.3 ms -> 85.0 ms +- 1.3 ms: 1.01x faster (-1%)
- python_startup_no_site: 9.18 ms +- 0.05 ms -> 9.09 ms +- 0.02 ms: 1.01x faster (-1%)
- genshi_xml: 74.8 ms +- 0.6 ms -> 74.2 ms +- 0.9 ms: 1.01x faster (-1%)
- nbody: 157 ms +- 2 ms -> 155 ms +- 2 ms: 1.01x faster (-1%)
- unpickle_list: 5.89 us +- 0.03 us -> 5.85 us +- 0.04 us: 1.01x faster (-1%)
- genshi_text: 36.7 ms +- 0.4 ms -> 36.5 ms +- 0.3 ms: 1.01x faster (-1%)
- dulwich_log: 80.5 ms +- 0.5 ms -> 80.0 ms +- 0.5 ms: 1.01x faster (-1%)
- regex_v8: 28.9 ms +- 0.1 ms -> 28.9 ms +- 0.1 ms: 1.00x faster (-0%)

Benchmark hidden because not significant (15): chameleon, crypto_pyaes, deltablue, logging_silent, logging_simple, meteor_contest, nqueens, pickle_dict, pickle_pure_python, raytrace, scimark_monte_carlo, sqlalchemy_imperative, sqlite_synth, telco, xml_etree_generate
Ignored benchmarks (3) of json/2019-09-16_14-25-master-89b8933bb537.json.gz: django_template, html5lib, tornado_http