typo here:

So, I think the AMD64 FreeBSD 10.x Shared 3.x uuid_create() function is wrong (if that is what it is using - was it/can it also use the uuid_generate* routines?

i.e., does AMD FreeBSD use uuid_create() or uuid_generate() - or can it use both?

Could someone with AMD try:
Modules/_uuidmodule.c

 +12  static PyObject *
   +13  py_uuid_generate_time_safe(void)
   +14  {
   +15      uuid_t uuid;
   +16  #ifdef HAVE_UUID_GENERATE_TIME_SAFE
   +17      int res;
   +18
   +19      res = uuid_generate_time_safe(uuid);
   +20      return Py_BuildValue("y#i", (const char *) uuid, sizeof(uuid), res);
   +21  #elif HAVE_UUID_GENERATE_TIME
   +22      uuid_generate_time(uuid);
   +23      return Py_BuildValue("y#O", (const char *) uuid, sizeof(uuid), Py_None);
   +24  #elif HAVE_UUID_CREATE
   +25      uint32_t status;
   +26      uuid_create(&uuid, &status);
   +27      return Py_BuildValue("y#i", (const char *) &uuid, sizeof(uuid), (int) status);
   +28  #else
   +29  #error "no uuid library function available"
   +30  #endif
   +31  }