Issue #29003 seems to be related to this one. I think that they can be solved the same way as done in Serhiy patch but I would like to suggest a different approach.
I suggest changing the check for DDL statement with a check for DML statement. We actually should start a transaction only for DML statements (https://docs.python.org/3/library/sqlite3.html#controlling-transactions) so all other statements (DDL, DCL and TCL) should not start a transaction.
The attached patch solve both this issue and issue #29003.