>> Do you mean comparison between current Python with PGO and patched
>> Python without PGO?
>
> Yes.

Ok, here you have. As expected, PGO compilation is faster than default compilation with my patch. PGO implements more optimization than just __attribute__((hot)), it also optimizes branches for example.

haypo@smithers$ python3 -m perf compare_to pgo.json.gz patch.json.gz -G --min-speed=5
Slower (56):
- regex_effbot: 4.30 ms +- 0.26 ms -> 5.77 ms +- 0.33 ms: 1.34x slower
- telco: 16.0 ms +- 1.1 ms -> 20.6 ms +- 0.4 ms: 1.29x slower
- xml_etree_process: 174 ms +- 15 ms -> 218 ms +- 29 ms: 1.25x slower
- xml_etree_generate: 205 ms +- 16 ms -> 254 ms +- 4 ms: 1.24x slower
- unpickle_list: 6.04 us +- 1.12 us -> 7.47 us +- 0.18 us: 1.24x slower
- call_simple: 10.6 ms +- 1.4 ms -> 13.1 ms +- 0.3 ms: 1.24x slower
- mako: 33.5 ms +- 0.3 ms -> 41.3 ms +- 0.9 ms: 1.23x slower
- pathlib: 37.0 ms +- 2.3 ms -> 44.7 ms +- 2.0 ms: 1.21x slower
- sqlite_synth: 7.56 us +- 0.20 us -> 8.97 us +- 0.18 us: 1.19x slower
- unpickle: 24.2 us +- 3.9 us -> 28.7 us +- 0.3 us: 1.18x slower
- chameleon: 23.4 ms +- 2.6 ms -> 27.4 ms +- 1.5 ms: 1.17x slower
- spectral_norm: 214 ms +- 7 ms -> 249 ms +- 9 ms: 1.17x slower
- nqueens: 210 ms +- 2 ms -> 244 ms +- 36 ms: 1.16x slower
- unpickle_pure_python: 717 us +- 10 us -> 831 us +- 66 us: 1.16x slower
- pickle: 18.7 us +- 4.3 us -> 21.6 us +- 3.3 us: 1.15x slower
- sympy_expand: 829 ms +- 39 ms -> 957 ms +- 28 ms: 1.15x slower
- genshi_text: 73.1 ms +- 3.2 ms -> 84.3 ms +- 1.1 ms: 1.15x slower
- pickle_list: 6.82 us +- 0.20 us -> 7.86 us +- 0.05 us: 1.15x slower
- sympy_str: 372 ms +- 28 ms -> 428 ms +- 3 ms: 1.15x slower
- xml_etree_parse: 231 ms +- 7 ms -> 266 ms +- 9 ms: 1.15x slower
- call_method_slots: 14.0 ms +- 1.3 ms -> 16.1 ms +- 1.2 ms: 1.15x slower
- sympy_sum: 169 ms +- 6 ms -> 194 ms +- 19 ms: 1.15x slower
- logging_format: 29.3 us +- 2.5 us -> 33.7 us +- 1.6 us: 1.15x slower
- logging_simple: 25.7 us +- 2.1 us -> 29.3 us +- 0.4 us: 1.14x slower
- genshi_xml: 159 ms +- 15 ms -> 182 ms +- 1 ms: 1.14x slower
- xml_etree_iterparse: 178 ms +- 3 ms -> 203 ms +- 5 ms: 1.14x slower
- pickle_pure_python: 1.06 ms +- 0.17 ms -> 1.21 ms +- 0.16 ms: 1.14x slower
- logging_silent: 618 ns +- 11 ns -> 705 ns +- 62 ns: 1.14x slower
- hexiom: 19.0 ms +- 0.2 ms -> 21.7 ms +- 0.2 ms: 1.14x slower
- html5lib: 184 ms +- 11 ms -> 209 ms +- 31 ms: 1.14x slower
- call_method: 14.3 ms +- 0.7 ms -> 16.3 ms +- 0.1 ms: 1.14x slower
- django_template: 324 ms +- 18 ms -> 368 ms +- 3 ms: 1.14x slower
- sympy_integrate: 37.9 ms +- 0.3 ms -> 43.0 ms +- 2.7 ms: 1.13x slower
- deltablue: 15.0 ms +- 2.0 ms -> 16.9 ms +- 1.0 ms: 1.12x slower
- call_method_unknown: 16.0 ms +- 0.4 ms -> 17.9 ms +- 0.2 ms: 1.12x slower
- 2to3: 611 ms +- 12 ms -> 677 ms +- 57 ms: 1.11x slower
- regex_compile: 300 ms +- 3 ms -> 332 ms +- 21 ms: 1.11x slower
- json_loads: 50.5 us +- 2.5 us -> 55.8 us +- 1.2 us: 1.10x slower
- unpack_sequence: 111 ns +- 5 ns -> 122 ns +- 1 ns: 1.10x slower
- pickle_dict: 53.2 us +- 3.7 us -> 58.1 us +- 3.7 us: 1.09x slower
- scimark_sor: 420 ms +- 60 ms -> 458 ms +- 12 ms: 1.09x slower
- scimark_lu: 398 ms +- 74 ms -> 434 ms +- 18 ms: 1.09x slower
- regex_dna: 227 ms +- 1 ms -> 247 ms +- 9 ms: 1.09x slower
- pidigits: 266 ms +- 33 ms -> 290 ms +- 10 ms: 1.09x slower
- chaos: 243 ms +- 2 ms -> 265 ms +- 3 ms: 1.09x slower
- crypto_pyaes: 197 ms +- 16 ms -> 215 ms +- 28 ms: 1.09x slower
- dulwich_log: 129 ms +- 15 ms -> 140 ms +- 8 ms: 1.08x slower
- sqlalchemy_imperative: 50.8 ms +- 0.9 ms -> 55.0 ms +- 1.8 ms: 1.08x slower
- meteor_contest: 173 ms +- 22 ms -> 187 ms +- 5 ms: 1.08x slower
- sqlalchemy_declarative: 268 ms +- 11 ms -> 290 ms +- 3 ms: 1.08x slower
- tornado_http: 335 ms +- 4 ms -> 361 ms +- 3 ms: 1.08x slower
- python_startup: 20.6 ms +- 0.6 ms -> 22.1 ms +- 0.9 ms: 1.08x slower
- python_startup_no_site: 8.37 ms +- 0.08 ms -> 9.00 ms +- 0.07 ms: 1.08x slower
- go: 518 ms +- 36 ms -> 557 ms +- 39 ms: 1.07x slower
- raytrace: 1.14 sec +- 0.08 sec -> 1.22 sec +- 0.02 sec: 1.07x slower
- scimark_fft: 594 ms +- 29 ms -> 627 ms +- 13 ms: 1.06x slower

Benchmark hidden because not significant (8): fannkuch, float, json_dumps, nbody, regex_v8, richards, scimark_monte_carlo, scimark_sparse_mat_mult