This looks like an extension of Issue 21058. Does the unlink() work on Windows? It seems to me that the file is configured to remove itself on close(), therefore I expect unlink() will raise an exception of its own. Also made some suggestions in the code review.

This problem also affects Python 2, if you fudge the right wrong parameters:

>>> NamedTemporaryFile((), prefix="blaua.")
Traceback (most recent call last):
  File "<stdin>", line 1, in <module>
  File "/home/proj/python/cpython/Lib/tempfile.py", line 477, in NamedTemporaryFile
    file = _os.fdopen(fd, mode, bufsize)
TypeError: argument 2 must be string, not tuple
[59140 refs]
>>> glob("/tmp/blaua.*")
['/tmp/blaua.AFtEqx']