I experience a segmentation fault with python 2.7 (both 2.7.5 and 2.7.6 tested on Ubuntu and Gentoo) when a large file is piped, the pipe is passed to os.popen and the process sends a SIGPIPE signal.

To create an easy to reproduce testcase grep can be used. See example attached.

To test first create a dummy file containing zeros, around 1 megabyte is enough:
for i in `seq 1 100000`; do echo "0123456789" >> dummy.txt; done

Then pipe it to the script attached like this:
cat dummy.txt | python2 minimal.py

Result is a Segmentation fault. The same code doesn't segfault with python 3.