Hi Fabio!  This is admittedly a corner-case use case, but if you think it would be worth it, we can very easily add this as a feature to PyPy (by making frame.f_locals writeable).  Then we can add the write inside pdb, and you could do the same for PyDev when running on PyPy.  It's certainly something that goes beyond the standard of CPython 2.7 but we'd consider it because it's obviously debug-only.