This may be too subjective, but here it goes:

PEP 8 discourages vertical alignment: "More than one space around an assignment (or other) operator to align it with another", but contrary to this rule, vertical alignment is used many times in the same paragraph, e.g.:
Yes: spam(1)
No:  spam (1)
If vertical alignment is so evil, the above should be changed to:
Yes: spam(1)
No: spam (1)

Disclosure: I use vertical alignment in my code quite often.

http://www.python.org/dev/peps/pep-0008/