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I haven't looked to see what the port is doing, but just
using configure, I find with 2.2.3 on FreeBSD 4.8:-
- test_locale fails becuase "en_US" is not a supported
locale; the test would have to use one of "en_US.US-ASCII",
"en_US.ISO8859-1" or "en_US.ISO8859-15" (I have no idea
which would be most appropriate).

- test_nis will fail if it can't find a NIS master for any
NIS map.

- test_socket_ssl & test_socketserver will be skipped if the
network resource is not enabled.

- test_sax & test_pyexpat both pass.

FreeBSD has its own expat package (which is using expat
1.95.6 on both 4.8 & 5.1).  pyexpat is a separately
selectable package/port.  If you haven't installed the
pyexpat package, or built same from the port, then test_sax
& test_pyexpat are both going to be skipped.

I'm still looking at a couple of other issues with building
on 5.1.

Given that FreeBSD 5.0 was a technology preview not intended
for production use, and a STABLE branch will not be declared
until at least after 5.2 is released, it will not be trivial
to keep track of build issues until release of 5.2.  I am
not in a position to track the FreeBSD 5.x CVS, but I will
try and keep up with releases.

I'm not sure whether anyone has yet stepped in to take Alan
Eldridge's place as maintainer of FreeBSD's ports of Python
& various modules. IMO, many of the issues here should have
been taken up with the Python port maintainer, rather than
being dealt with in Python's tracker (I tried to contact
AlanE about some of this not long before he died).