the pywin32 DLLs have 2 heads.  They are Python extension modules as well as regular DLLs.  They are built by distutils and therefore have no manifests - I think many packages use distutils to build their extension modules - it is just that they usually don't have a .dll extension.

I fear that simply adding a manifest to those DLLs will put them in the same position we have before issue4120 was addressed, and these .dlls do need a way to be installed into System32 (or somewhere else on the global PATH) to function as COM servers etc.  I need to experiment with this.