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After some discussion on the SIG it turns out this is a rather complicated problem, because WNE() may cause callbacks to be called (for Carbon Event handlers, for instance), and releasing the GIL would mean those callbacks would be hosed.

A solution will have to have all callback wrappers acquire the GIL, and it will either have to make very sure we never enter WNE() or friends with the GIL held, or the callback code will need to be able to handle both the case of being called with the GIL held and the case of being called without it.