Hello, 
While I was trying to install Python version 3.9.4 on Windows 10 64bit, Error 0x80070643 - Fatal error during installation is showing, with a message saying " install the process cannot access the file because another process has locked a portion of the file", 

Note: There was an older version of Python installed on my laptop in 2018, but a while ago i did a system format, but some of the .XMl and .py files still there ( i don't know if that's the case)

Core_AllUsers (https://pastebin.com/iAZGTrkx)

The error message suggests somethng else is using something in an existing 3.9 directory, and that you should close everything and reboot your machine and try again without running anything else.

Hello Terry, thank you for replying.
I tried many times to reboot and no luck.
Also i noticed that when i tried to install an older version like Python 2 the installation done without errors.

Also if you are talking about the location of installation, i tried to install it in somewhere else and still not working

Can someone help please, i need it in my project

Hi Marwan

If you look in your %TEMP% directory for the log file you attached, you'll find some more similar log files. Could you attach those as well? One of them will have the actual issue in it.

Done, i uploaded a rar with all the log files in %TEMP%

See if the your problem is solved by following https://docs.microsoft.com/en-us/troubleshoot/windows-server/application-management/msi-installation-error-1603.

Hello Shreyan,
unfortunately still not working, I tried all the solutions and none worked. still showing the same error.

This is the full error message (and sorry I just saw that you put it on pastebin in the first post).

MSI (s) (18:04) [13:13:04:342]: SECREPAIR: Hash Database: C:\Windows\Installer\SourceHash{1C17C2CE-B315-4C1C-885A-E37181C7368E}
MSI (s) (18:04) [13:13:04:342]: Note: 1: 2203 2: C:\Windows\Installer\SourceHash{1C17C2CE-B315-4C1C-885A-E37181C7368E} 3: -2147023504 
MSI (s) (18:04) [13:13:04:342]: SECREPAIR: Error in CreateDatabase for write
MSI (s) (18:04) [13:13:04:342]: SECUREREPAIR: SecureRepair Failed. Error code: 89b55C5DDD8

This file isn't ours, so there's nothing we can do. You could try running some of the builtin troubleshooters, or perhaps the "sfc /scannow" command (in an elevated prompt) might help. It's possible that you have an aggressive antivirus or admin policy that you may be able to disable. Otherwise, for a corrupt install database, I'd guess you're looking at a Windows reset/reinstall.

If you have any success, please let us know what worked. If it turns out to be something within our control, we can try and make a change, but I suspect it'll just be handy to know for next time someone hits an issue like this.

Hello Steve

I did a Windows format and now I can successfully install Python, Thanks for helping

Thanks for the update Marwan. I'm closing because there doesn't seem to be any followup possible on our side.