diff --git a/Doc/library/sqlite3.rst b/Doc/library/sqlite3.rst
index 1da5c7f3ab..869fb59e7e 100644
--- a/Doc/library/sqlite3.rst
+++ b/Doc/library/sqlite3.rst
@@ -458,7 +458,7 @@ Connection Objects
       .. versionadded:: 3.3
 
 
-   .. method:: enable_load_extension(enabled)
+   .. method:: enable_load_extension(enabled, /)
 
       This routine allows/disallows the SQLite engine to load SQLite extensions
       from shared libraries.  SQLite extensions can define new functions,
@@ -467,8 +467,14 @@ Connection Objects
 
       Loadable extensions are disabled by default. See [#f1]_.
 
+      Since Python 3.10, the SQL function ``load_extension()`` is not enabled,
+      in order to prevent SQL injections attackers to load extensions.
+
       .. versionadded:: 3.2
 
+      .. versionchanged:: 3.10
+         The SQL ``load_extension()`` API is no longer enabled.
+
       .. literalinclude:: ../includes/sqlite3/load_extension.py
 
    .. method:: load_extension(path)
diff --git a/Modules/_sqlite/connection.c b/Modules/_sqlite/connection.c
index 9bf2a35ab0..abdf57efd4 100644
--- a/Modules/_sqlite/connection.c
+++ b/Modules/_sqlite/connection.c
@@ -1143,20 +1143,21 @@ pysqlite_connection_enable_load_extension_impl(pysqlite_Connection *self,
                                                int onoff)
 /*[clinic end generated code: output=9cac37190d388baf input=5c0da5b121121cbc]*/
 {
-    int rc;
-
     if (!pysqlite_check_thread(self) || !pysqlite_check_connection(self)) {
         return NULL;
     }
 
-    rc = sqlite3_enable_load_extension(self->db, onoff);
+    int rc = sqlite3_db_config(self->db,
+                               SQLITE_DBCONFIG_ENABLE_LOAD_EXTENSION,
+                               onoff ? 1 : 0,
+                               NULL);
 
     if (rc != SQLITE_OK) {
-        PyErr_SetString(pysqlite_OperationalError, "Error enabling load extension");
+        PyErr_SetString(pysqlite_OperationalError,
+                        "Error enabling load extension");
         return NULL;
-    } else {
-        Py_RETURN_NONE;
     }
+    Py_RETURN_NONE;
 }
 
 /*[clinic input]