diff --git a/Python/compile.c b/Python/compile.c
index a992e4b465..fb93c78911 100644
--- a/Python/compile.c
+++ b/Python/compile.c
@@ -1691,7 +1691,8 @@ compiler_body(struct compiler *c, asdl_seq *stmts)
         c->u->u_lineno = st->lineno;
     }
     /* Every annotated class and module should have __annotations__. */
-    if (find_ann(stmts)) {
+    /* if not -OO mode, setup annotations */
+    if (find_ann(stmts) && c->c_optimize < 2) {
         ADDOP(c, SETUP_ANNOTATIONS);
     }
     if (!asdl_seq_LEN(stmts))
@@ -1735,7 +1736,8 @@ compiler_mod(struct compiler *c, mod_ty mod)
         }
         break;
     case Interactive_kind:
-        if (find_ann(mod->v.Interactive.body)) {
+        /* if not -OO mode, setup annotations */
+        if (find_ann(mod->v.Interactive.body) && c->c_optimize < 2) {
             ADDOP(c, SETUP_ANNOTATIONS);
         }
         c->c_interactive = 1;
@@ -2105,7 +2107,12 @@ compiler_function(struct compiler *c, stmt_ty s, int is_async)
         return 0;
     }
 
-    annotations = compiler_visit_annotations(c, args, returns);
+    /* if not -OO mode, add annotations */
+    if (c->c_optimize < 2) {
+        annotations = compiler_visit_annotations(c, args, returns);
+    } else {
+        annotations = -1;
+    }
     if (annotations == 0) {
         return 0;
     }
@@ -5032,6 +5039,12 @@ compiler_annassign(struct compiler *c, stmt_ty s)
         VISIT(c, expr, s->v.AnnAssign.value);
         VISIT(c, expr, targ);
     }
+
+    /* if -OO mode, skip annotations */
+    if (c->c_optimize >= 2) {
+        return 1;
+    }
+
     switch (targ->kind) {
     case Name_kind:
         /* If we have a simple name in a module or class, store annotation. */