diff -r 598a00a4540a Lib/sqlite3/test/transactions.py
--- a/Lib/sqlite3/test/transactions.py	Fri Dec 16 10:00:53 2016 +0100
+++ b/Lib/sqlite3/test/transactions.py	Fri Dec 16 14:53:07 2016 +0200
@@ -179,6 +179,15 @@ class TransactionalDDL(unittest.TestCase
         result = self.con.execute("select * from test").fetchall()
         self.assertEqual(result, [])
 
+    def CheckImmediateTransactionalDDL(self):
+        # You can achieve transactional DDL by issuing a BEGIN
+        # statement manually.
+        self.con.execute("begin immediate")
+        self.con.execute("create table test(i)")
+        self.con.rollback()
+        with self.assertRaises(sqlite.OperationalError):
+            self.con.execute("select * from test")
+
     def CheckTransactionalDDL(self):
         # You can achieve transactional DDL by issuing a BEGIN
         # statement manually.
diff -r 598a00a4540a Modules/_sqlite/statement.c
--- a/Modules/_sqlite/statement.c	Fri Dec 16 10:00:53 2016 +0100
+++ b/Modules/_sqlite/statement.c	Fri Dec 16 14:53:07 2016 +0200
@@ -86,7 +86,8 @@ int pysqlite_statement_create(pysqlite_S
 
         self->is_ddl = (PyOS_strnicmp(p, "create ", 7) == 0)
                     || (PyOS_strnicmp(p, "drop ", 5) == 0)
-                    || (PyOS_strnicmp(p, "reindex ", 8) == 0);
+                    || (PyOS_strnicmp(p, "reindex ", 8) == 0)
+                    || (PyOS_strnicmp(p, "begin ", 6) == 0);
         break;
     }