diff -r b671ac7ae620 Lib/test/libregrtest/refleak.py
--- a/Lib/test/libregrtest/refleak.py	Wed Nov 09 09:43:08 2016 -0500
+++ b/Lib/test/libregrtest/refleak.py	Wed Nov 09 20:48:40 2016 +0200
@@ -184,6 +184,14 @@ def dash_R_cleanup(fs, ps, pic, zdc, abc
     else:
         ctypes._reset_cache()
 
+    try:
+        typing = sys.modules['typing']
+    except KeyError:
+        pass
+    else:
+        for f in typing._cleanups:
+            f()
+
     # Collect cyclic trash and read memory statistics immediately after.
     func1 = sys.getallocatedblocks
     func2 = sys.gettotalrefcount
diff -r b671ac7ae620 Lib/typing.py
--- a/Lib/typing.py	Wed Nov 09 09:43:08 2016 -0500
+++ b/Lib/typing.py	Wed Nov 09 20:48:40 2016 +0200
@@ -613,12 +613,15 @@ def _check_generic(cls, parameters):
                         ("many" if alen > elen else "few", repr(cls), alen, elen))
 
 
+_cleanups = []
+
 def _tp_cache(func):
     """ Caching for __getitem__ of generic types with a fallback to
     original function for non-hashable arguments.
     """
 
     cached = functools.lru_cache()(func)
+    _cleanups.append(cached.cache_clear)
     @functools.wraps(func)
     def inner(*args, **kwds):
         try: