diff -r 6247dd0f230e Lib/distutils/sysconfig.py
--- a/Lib/distutils/sysconfig.py	Sat Jun 04 14:40:03 2016 -0700
+++ b/Lib/distutils/sysconfig.py	Sun Jun 05 00:38:11 2016 +0200
@@ -242,6 +242,8 @@
         return os.path.join(_sys_home or project_base, "Makefile")
     lib_dir = get_python_lib(plat_specific=0, standard_lib=1)
     config_file = 'config-{}{}'.format(get_python_version(), build_flags)
+    if hasattr(sys.implementation, '_multiarch'):
+        config_file += '-%s' % sys.implementation._multiarch
     return os.path.join(lib_dir, config_file, 'Makefile')
 
 
diff -r 6247dd0f230e Lib/plat-linux/regen
--- a/Lib/plat-linux/regen	Sat Jun 04 14:40:03 2016 -0700
+++ b/Lib/plat-linux/regen	Sun Jun 05 00:38:11 2016 +0200
@@ -1,8 +1,33 @@
 #! /bin/sh
 case `uname` in
-Linux*)	;;
+Linux*|GNU*)	;;
 *)	echo Probably not on a Linux system 1>&2
 	exit 1;;
 esac
-set -v
-h2py -i '(u_long)' /usr/include/sys/types.h /usr/include/netinet/in.h /usr/include/dlfcn.h
+if [ -z "$CC" ]; then
+    echo >&2 "$(basename $0): CC is not set"
+    exit 1
+fi
+headers="sys/types.h netinet/in.h dlfcn.h"
+incdirs="$(echo $($CC -v -E - < /dev/null 2>&1|awk '/^#include/, /^End of search/' | grep '^ '))"
+if [ -z "$incdirs" ]; then
+    incdirs="/usr/include"
+fi
+for h in $headers; do
+    absh=
+    for d in $incdirs; do
+	if [ -f "$d/$h" ]; then
+	    absh="$d/$h"
+	    break
+	fi
+    done
+    if [ -n "$absh" ]; then
+	absheaders="$absheaders $absh"
+    else
+	echo >&2 "$(basename $0): header $h not found"
+	exit 1
+    fi
+done
+
+set -x
+${H2PY:-h2py} -i '(u_long)' $absheaders
diff -r 6247dd0f230e Lib/sysconfig.py
--- a/Lib/sysconfig.py	Sat Jun 04 14:40:03 2016 -0700
+++ b/Lib/sysconfig.py	Sun Jun 05 00:38:11 2016 +0200
@@ -337,6 +337,8 @@
         config_dir_name = 'config-%s%s' % (_PY_VERSION_SHORT, sys.abiflags)
     else:
         config_dir_name = 'config'
+    if hasattr(sys.implementation, '_multiarch'):
+        config_dir_name += '-%s' % sys.implementation._multiarch
     return os.path.join(get_path('stdlib'), config_dir_name, 'Makefile')
 
 def _generate_posix_vars():
@@ -379,7 +381,7 @@
     # _sysconfigdata module manually and populate it with the build vars.
     # This is more than sufficient for ensuring the subsequent call to
     # get_platform() succeeds.
-    name = '_sysconfigdata'
+    name = '_sysconfigdata_' + sys.abiflags
     if 'darwin' in sys.platform:
         import types
         module = types.ModuleType(name)
@@ -405,7 +407,9 @@
 def _init_posix(vars):
     """Initialize the module as appropriate for POSIX systems."""
     # _sysconfigdata is generated at build time, see _generate_posix_vars()
-    from _sysconfigdata import build_time_vars
+    name = '_sysconfigdata_' + sys.abiflags
+    _temp = __import__(name, globals(), locals(), ['build_time_vars'], 0)
+    build_time_vars = _temp.build_time_vars
     vars.update(build_time_vars)
 
 def _init_non_posix(vars):
diff -r 6247dd0f230e Makefile.pre.in
--- a/Makefile.pre.in	Sat Jun 04 14:40:03 2016 -0700
+++ b/Makefile.pre.in	Sun Jun 05 00:38:11 2016 +0200
@@ -109,6 +109,7 @@
 
 # Multiarch directory (may be empty)
 MULTIARCH=	@MULTIARCH@
+MULTIARCH_CPPFLAGS = @MULTIARCH_CPPFLAGS@
 
 # Install prefix for architecture-independent files
 prefix=		@prefix@
@@ -784,6 +785,7 @@
 Python/sysmodule.o: $(srcdir)/Python/sysmodule.c Makefile
 	$(CC) -c $(PY_CORE_CFLAGS) \
 		-DABIFLAGS='"$(ABIFLAGS)"' \
+		$(MULTIARCH_CPPFLAGS) \
 		-o $@ $(srcdir)/Python/sysmodule.c
 
 $(IO_OBJS): $(IO_H)
@@ -1259,7 +1261,7 @@
 		else	true; \
 		fi; \
 	done
-	@for i in $(srcdir)/Lib/*.py `cat pybuilddir.txt`/_sysconfigdata.py; \
+	@for i in $(srcdir)/Lib/*.py; \
 	do \
 		if test -x $$i; then \
 			$(INSTALL_SCRIPT) $$i $(DESTDIR)$(LIBDEST); \
@@ -1294,6 +1296,10 @@
 			esac; \
 		done; \
 	done
+	$(INSTALL_DATA) `cat pybuilddir.txt`/_sysconfigdata_$(ABIFLAGS).py \
+		$(DESTDIR)$(LIBDEST)/$(PLATDIR); \
+	echo $(INSTALL_DATA) `cat pybuilddir.txt`/_sysconfigdata_$(ABIFLAGS).py \
+		$(LIBDEST)/$(PLATDIR)
 	$(INSTALL_DATA) $(srcdir)/LICENSE $(DESTDIR)$(LIBDEST)/LICENSE.txt
 	if test -d $(DESTDIR)$(LIBDEST)/distutils/tests; then \
 		$(INSTALL_DATA) $(srcdir)/Modules/xxmodule.c \
@@ -1332,13 +1338,19 @@
 		$(PYTHON_FOR_BUILD) -m lib2to3.pgen2.driver $(DESTDIR)$(LIBDEST)/lib2to3/PatternGrammar.txt
 
 # Create the PLATDIR source directory, if one wasn't distributed..
+# For multiarch targets, use the plat-linux/regen script.
 $(srcdir)/Lib/$(PLATDIR):
 	mkdir $(srcdir)/Lib/$(PLATDIR)
-	cp $(srcdir)/Lib/plat-generic/regen $(srcdir)/Lib/$(PLATDIR)/regen
+	if [ -n "$(MULTIARCH)" ]; then \
+	  cp $(srcdir)/Lib/plat-linux/regen $(srcdir)/Lib/$(PLATDIR)/regen; \
+	else \
+	  cp $(srcdir)/Lib/plat-generic/regen $(srcdir)/Lib/$(PLATDIR)/regen; \
+	fi; \
 	export PATH; PATH="`pwd`:$$PATH"; \
 	export PYTHONPATH; PYTHONPATH="`pwd`/Lib"; \
 	export DYLD_FRAMEWORK_PATH; DYLD_FRAMEWORK_PATH="`pwd`"; \
 	export EXE; EXE="$(BUILDEXE)"; \
+	export CC; CC="$(CC)"; \
 	if [ -n "$(MULTIARCH)" ]; then export MULTIARCH; MULTIARCH=$(MULTIARCH); fi; \
 	export PYTHON_FOR_BUILD; \
 	if [ "$(BUILD_GNU_TYPE)" = "$(HOST_GNU_TYPE)" ]; then \
@@ -1346,6 +1358,7 @@
 	else \
 	  PYTHON_FOR_BUILD="$(PYTHON_FOR_BUILD)"; \
 	fi; \
+	export H2PY; H2PY="$$PYTHON_FOR_BUILD $(abs_srcdir)/Tools/scripts/h2py.py"; \
 	cd $(srcdir)/Lib/$(PLATDIR); $(RUNSHARED) ./regen
 
 python-config: $(srcdir)/Misc/python-config.in Misc/python-config.sh
@@ -1444,7 +1457,7 @@
 		--install-scripts=$(BINDIR) \
 		--install-platlib=$(DESTSHARED) \
 		--root=$(DESTDIR)/
-	-rm $(DESTDIR)$(DESTSHARED)/_sysconfigdata.py
+	-rm $(DESTDIR)$(DESTSHARED)/_sysconfigdata_$(ABIFLAGS).py
 	-rm -r $(DESTDIR)$(DESTSHARED)/__pycache__
 
 # Here are a couple of targets for MacOSX again, to install a full
@@ -1623,6 +1636,9 @@
 	-rm -rf build platform
 	-rm -rf $(PYTHONFRAMEWORKDIR)
 	-rm -f python-config.py python-config
+	if [ -n "$(MULTIARCH)" ]; then \
+	  rm -rf $(srcdir)/Lib/$(PLATDIR); \
+	fi
 
 # Make things extra clean, before making a distribution:
 # remove all generated files, even Makefile[.pre]
diff -r 6247dd0f230e Python/sysmodule.c
--- a/Python/sysmodule.c	Sat Jun 04 14:40:03 2016 -0700
+++ b/Python/sysmodule.c	Sun Jun 05 00:38:11 2016 +0200
@@ -1693,6 +1693,16 @@
     if (res < 0)
         goto error;
 
+#ifdef MULTIARCH
+    value = PyUnicode_FromString(MULTIARCH);
+    if (value == NULL)
+        goto error;
+    res = PyDict_SetItemString(impl_info, "_multiarch", value);
+    Py_DECREF(value);
+    if (res < 0)
+        goto error;
+#endif
+
     /* dict ready */
 
     ns = _PyNamespace_New(impl_info);
diff -r 6247dd0f230e configure
--- a/configure	Sat Jun 04 14:40:03 2016 -0700
+++ b/configure	Sun Jun 05 00:38:11 2016 +0200
@@ -704,6 +704,7 @@
 BUILDEXEEXT
 EGREP
 NO_AS_NEEDED
+MULTIARCH_CPPFLAGS
 PLATFORM_TRIPLET
 PLATDIR
 MULTIARCH
@@ -776,6 +777,7 @@
 docdir
 oldincludedir
 includedir
+runstatedir
 localstatedir
 sharedstatedir
 sysconfdir
@@ -886,6 +888,7 @@
 sysconfdir='${prefix}/etc'
 sharedstatedir='${prefix}/com'
 localstatedir='${prefix}/var'
+runstatedir='${localstatedir}/run'
 includedir='${prefix}/include'
 oldincludedir='/usr/include'
 docdir='${datarootdir}/doc/${PACKAGE_TARNAME}'
@@ -1138,6 +1141,15 @@
   | -silent | --silent | --silen | --sile | --sil)
     silent=yes ;;
 
+  -runstatedir | --runstatedir | --runstatedi | --runstated \
+  | --runstate | --runstat | --runsta | --runst | --runs \
+  | --run | --ru | --r)
+    ac_prev=runstatedir ;;
+  -runstatedir=* | --runstatedir=* | --runstatedi=* | --runstated=* \
+  | --runstate=* | --runstat=* | --runsta=* | --runst=* | --runs=* \
+  | --run=* | --ru=* | --r=*)
+    runstatedir=$ac_optarg ;;
+
   -sbindir | --sbindir | --sbindi | --sbind | --sbin | --sbi | --sb)
     ac_prev=sbindir ;;
   -sbindir=* | --sbindir=* | --sbindi=* | --sbind=* | --sbin=* \
@@ -1275,7 +1287,7 @@
 for ac_var in	exec_prefix prefix bindir sbindir libexecdir datarootdir \
 		datadir sysconfdir sharedstatedir localstatedir includedir \
 		oldincludedir docdir infodir htmldir dvidir pdfdir psdir \
-		libdir localedir mandir
+		libdir localedir mandir runstatedir
 do
   eval ac_val=\$$ac_var
   # Remove trailing slashes.
@@ -1428,6 +1440,7 @@
   --sysconfdir=DIR        read-only single-machine data [PREFIX/etc]
   --sharedstatedir=DIR    modifiable architecture-independent data [PREFIX/com]
   --localstatedir=DIR     modifiable single-machine data [PREFIX/var]
+  --runstatedir=DIR       modifiable per-process data [LOCALSTATEDIR/run]
   --libdir=DIR            object code libraries [EPREFIX/lib]
   --includedir=DIR        C header files [PREFIX/include]
   --oldincludedir=DIR     C header files for non-gcc [/usr/include]
@@ -2876,6 +2889,7 @@
 ac_config_headers="$ac_config_headers pyconfig.h"
 
 
+
 ac_aux_dir=
 for ac_dir in "$srcdir" "$srcdir/.." "$srcdir/../.."; do
   if test -f "$ac_dir/install-sh"; then
@@ -5331,9 +5345,16 @@
     as_fn_error $? "internal configure error for the platform triplet, please file a bug report" "$LINENO" 5
   fi
 fi
-PLATDIR=plat-$MACHDEP
-
-
+if test x$PLATFORM_TRIPLET = x; then
+  PLATDIR=plat-$MACHDEP
+else
+  PLATDIR=plat-$PLATFORM_TRIPLET
+fi
+
+
+if test x$MULTIARCH != x; then
+  MULTIARCH_CPPFLAGS="-DMULTIARCH=\\\"$MULTIARCH\\\""
+fi
 
 
 { $as_echo "$as_me:${as_lineno-$LINENO}: checking for -Wl,--no-as-needed" >&5
@@ -14767,7 +14788,11 @@
 $as_echo "$LDVERSION" >&6; }
 
 
-LIBPL='$(prefix)'"/lib/python${VERSION}/config-${LDVERSION}"
+if test x$PLATFORM_TRIPLET = x; then
+  LIBPL='$(prefix)'"/lib/python${VERSION}/config-${LDVERSION}"
+else
+  LIBPL='$(prefix)'"/lib/python${VERSION}/config-${LDVERSION}-${PLATFORM_TRIPLET}"
+fi
 
 
 # Check whether right shifting a negative integer extends the sign bit
diff -r 6247dd0f230e configure.ac
--- a/configure.ac	Sat Jun 04 14:40:03 2016 -0700
+++ b/configure.ac	Sun Jun 05 00:38:11 2016 +0200
@@ -872,10 +872,17 @@
     AC_MSG_ERROR([internal configure error for the platform triplet, please file a bug report])
   fi
 fi
-PLATDIR=plat-$MACHDEP
+if test x$PLATFORM_TRIPLET = x; then
+  PLATDIR=plat-$MACHDEP
+else
+  PLATDIR=plat-$PLATFORM_TRIPLET
+fi
 AC_SUBST(PLATDIR)
 AC_SUBST(PLATFORM_TRIPLET)
-
+if test x$MULTIARCH != x; then
+  MULTIARCH_CPPFLAGS="-DMULTIARCH=\\\"$MULTIARCH\\\""
+fi
+AC_SUBST(MULTIARCH_CPPFLAGS)
 
 AC_MSG_CHECKING([for -Wl,--no-as-needed])
 save_LDFLAGS="$LDFLAGS"
@@ -4462,7 +4469,11 @@
 
 dnl define LIBPL after ABIFLAGS and LDVERSION is defined.
 AC_SUBST(PY_ENABLE_SHARED)
-LIBPL='$(prefix)'"/lib/python${VERSION}/config-${LDVERSION}"
+if test x$PLATFORM_TRIPLET = x; then
+  LIBPL='$(prefix)'"/lib/python${VERSION}/config-${LDVERSION}"
+else
+  LIBPL='$(prefix)'"/lib/python${VERSION}/config-${LDVERSION}-${PLATFORM_TRIPLET}"
+fi
 AC_SUBST(LIBPL)
 
 # Check whether right shifting a negative integer extends the sign bit