diff -r 811ccdee6f87 Lib/distutils/tests/test_build_ext.py
--- a/Lib/distutils/tests/test_build_ext.py	Wed May 04 09:44:44 2016 +0300
+++ b/Lib/distutils/tests/test_build_ext.py	Thu May 05 18:12:52 2016 +0200
@@ -20,6 +20,7 @@
 # Don't load the xx module more than once.
 ALREADY_TESTED = False
 
+cross_compiled = (sysconfig.get_config_var('cross_compiling') == 'yes')
 
 class BuildExtTestCase(TempdirManager,
                        LoggingSilencer,
@@ -40,6 +41,7 @@
     def build_ext(self, *args, **kwargs):
         return build_ext(*args, **kwargs)
 
+    @unittest.skipIf(cross_compiled, 'interpreter is cross-compiled')
     def test_build_ext(self):
         global ALREADY_TESTED
         copy_xxmodule_c(self.tmp_dir)
@@ -287,6 +289,7 @@
         cmd.run()
         self.assertEqual(cmd.compiler, 'unix')
 
+    @unittest.skipIf(cross_compiled, 'interpreter is cross-compiled')
     def test_get_outputs(self):
         tmp_dir = self.mkdtemp()
         c_file = os.path.join(tmp_dir, 'foo.c')
diff -r 811ccdee6f87 Lib/distutils/tests/test_config_cmd.py
--- a/Lib/distutils/tests/test_config_cmd.py	Wed May 04 09:44:44 2016 +0300
+++ b/Lib/distutils/tests/test_config_cmd.py	Thu May 05 18:17:23 2016 +0200
@@ -7,6 +7,9 @@
 from distutils.command.config import dump_file, config
 from distutils.tests import support
 from distutils import log
+from distutils import sysconfig
+
+cross_compiled = (sysconfig.get_config_var('cross_compiling') == 'yes')
 
 class ConfigTestCase(support.LoggingSilencer,
                      support.TempdirManager,
@@ -37,6 +40,7 @@
         dump_file(this_file, 'I am the header')
         self.assertEqual(len(self._logs), numlines+1)
 
+    @unittest.skipIf(cross_compiled, 'interpreter is cross-compiled')
     @unittest.skipIf(sys.platform == 'win32', "can't test on Windows")
     def test_search_cpp(self):
         pkg_dir, dist = self.create_dist()
diff -r 811ccdee6f87 Lib/distutils/tests/test_install.py
--- a/Lib/distutils/tests/test_install.py	Wed May 04 09:44:44 2016 +0300
+++ b/Lib/distutils/tests/test_install.py	Thu May 05 18:13:46 2016 +0200
@@ -18,6 +18,7 @@
 
 from distutils.tests import support
 
+cross_compiled = (sysconfig.get_config_var('cross_compiling') == 'yes')
 
 def _make_ext_name(modname):
     return modname + sysconfig.get_config_var('EXT_SUFFIX')
@@ -195,6 +196,7 @@
                     'UNKNOWN-0.0.0-py%s.%s.egg-info' % sys.version_info[:2]]
         self.assertEqual(found, expected)
 
+    @unittest.skipIf(cross_compiled, 'interpreter is cross-compiled')
     def test_record_extensions(self):
         install_dir = self.mkdtemp()
         project_dir, dist = self.create_dist(ext_modules=[
diff -r 811ccdee6f87 Lib/distutils/tests/test_sysconfig.py
--- a/Lib/distutils/tests/test_sysconfig.py	Wed May 04 09:44:44 2016 +0300
+++ b/Lib/distutils/tests/test_sysconfig.py	Fri May 06 09:44:19 2016 +0200
@@ -11,6 +11,8 @@
 from distutils.tests import support
 from test.support import TESTFN, run_unittest, check_warnings
 
+cross_compiled = (sysconfig.get_config_var('cross_compiling') == 'yes')
+
 class SysconfigTestCase(support.EnvironGuard, unittest.TestCase):
     def setUp(self):
         super(SysconfigTestCase, self).setUp()
@@ -39,6 +41,7 @@
         self.assertNotEqual(sysconfig.get_python_lib(),
                             sysconfig.get_python_lib(prefix=TESTFN))
 
+    @unittest.skipIf(cross_compiled, 'interpreter is cross-compiled')
     def test_get_python_inc(self):
         inc_dir = sysconfig.get_python_inc()
         # This is not much of a test.  We make sure Python.h exists