diff -r 14cb17682831 Modules/_sqlite/connection.c
--- a/Modules/_sqlite/connection.c	Tue Apr 26 11:47:10 2016 +0000
+++ b/Modules/_sqlite/connection.c	Sat Apr 30 13:16:16 2016 +0300
@@ -110,8 +110,13 @@
         return -1;
     }
     Py_BEGIN_ALLOW_THREADS
+#ifdef HAVE_SQLITE3_OPEN_V2
+    rc = sqlite3_open_v2(database, &self->db,
+                         SQLITE_OPEN_READWRITE | SQLITE_OPEN_CREATE, NULL);
+#else
     rc = sqlite3_open(database, &self->db);
 #endif
+#endif
     Py_END_ALLOW_THREADS
 
     if (rc != SQLITE_OK) {
@@ -250,7 +255,7 @@
     /* Clean up if user has not called .close() explicitly. */
     if (self->db) {
         Py_BEGIN_ALLOW_THREADS
-        sqlite3_close(self->db);
+        SQLITE3_CLOSE(self->db);
         Py_END_ALLOW_THREADS
     }
 
@@ -337,7 +342,7 @@
 
     if (self->db) {
         Py_BEGIN_ALLOW_THREADS
-        rc = sqlite3_close(self->db);
+        rc = SQLITE3_CLOSE(self->db);
         Py_END_ALLOW_THREADS
 
         if (rc != SQLITE_OK) {
@@ -378,7 +383,7 @@
     sqlite3_stmt* statement;
 
     Py_BEGIN_ALLOW_THREADS
-    rc = sqlite3_prepare(self->db, self->begin_statement, -1, &statement, &tail);
+    rc = SQLITE3_PREPARE(self->db, self->begin_statement, -1, &statement, &tail);
     Py_END_ALLOW_THREADS
 
     if (rc != SQLITE_OK) {
@@ -424,7 +429,7 @@
         pysqlite_do_all_statements(self, ACTION_RESET, 0);
 
         Py_BEGIN_ALLOW_THREADS
-        rc = sqlite3_prepare(self->db, "COMMIT", -1, &statement, &tail);
+        rc = SQLITE3_PREPARE(self->db, "COMMIT", -1, &statement, &tail);
         Py_END_ALLOW_THREADS
         if (rc != SQLITE_OK) {
             _pysqlite_seterror(self->db, NULL);
@@ -470,7 +475,7 @@
         pysqlite_do_all_statements(self, ACTION_RESET, 1);
 
         Py_BEGIN_ALLOW_THREADS
-        rc = sqlite3_prepare(self->db, "ROLLBACK", -1, &statement, &tail);
+        rc = SQLITE3_PREPARE(self->db, "ROLLBACK", -1, &statement, &tail);
         Py_END_ALLOW_THREADS
         if (rc != SQLITE_OK) {
             _pysqlite_seterror(self->db, NULL);
diff -r 14cb17682831 Modules/_sqlite/cursor.c
--- a/Modules/_sqlite/cursor.c	Tue Apr 26 11:47:10 2016 +0000
+++ b/Modules/_sqlite/cursor.c	Sat Apr 30 13:16:16 2016 +0300
@@ -788,7 +788,7 @@
 
     while (1) {
         Py_BEGIN_ALLOW_THREADS
-        rc = sqlite3_prepare(self->connection->db,
+        rc = SQLITE3_PREPARE(self->connection->db,
                              script_cstr,
                              -1,
                              &statement,
diff -r 14cb17682831 Modules/_sqlite/statement.c
--- a/Modules/_sqlite/statement.c	Tue Apr 26 11:47:10 2016 +0000
+++ b/Modules/_sqlite/statement.c	Sat Apr 30 13:16:16 2016 +0300
@@ -73,7 +73,7 @@
     self->sql = sql;
 
     Py_BEGIN_ALLOW_THREADS
-    rc = sqlite3_prepare(connection->db,
+    rc = SQLITE3_PREPARE(connection->db,
                          sql_cstr,
                          -1,
                          &self->st,
@@ -314,7 +314,7 @@
     }
 
     Py_BEGIN_ALLOW_THREADS
-    rc = sqlite3_prepare(self->db,
+    rc = SQLITE3_PREPARE(self->db,
                          sql_cstr,
                          -1,
                          &new_st,
diff -r 14cb17682831 Modules/_sqlite/util.h
--- a/Modules/_sqlite/util.h	Tue Apr 26 11:47:10 2016 +0000
+++ b/Modules/_sqlite/util.h	Sat Apr 30 13:16:16 2016 +0300
@@ -39,4 +39,16 @@
 PyObject * _pysqlite_long_from_int64(sqlite_int64 value);
 sqlite_int64 _pysqlite_long_as_int64(PyObject * value);
 
+#ifdef HAVE_SQLITE3_PREPARE_V2
+#define SQLITE3_PREPARE sqlite3_prepare_v2
+#else
+#define SQLITE3_PREPARE sqlite3_prepare
 #endif
+
+#ifdef HAVE_SQLITE3_CLOSE_V2
+#define SQLITE3_CLOSE sqlite3_close_v2
+#else
+#define SQLITE3_CLOSE sqlite3_close
+#endif
+
+#endif
diff -r 14cb17682831 configure.ac
--- a/configure.ac	Tue Apr 26 11:47:10 2016 +0000
+++ b/configure.ac	Sat Apr 30 13:16:16 2016 +0300
@@ -2707,6 +2707,14 @@
 
 AC_MSG_RESULT($enable_loadable_sqlite_extensions)
 
+# Check for support of sqlite3 _v2 interface
+AC_CHECK_LIB(sqlite3, sqlite3_prepare_v2,
+             AC_DEFINE(HAVE_SQLITE3_PREPARE_V2, 1, [Define if the sqlite3 library has sqlite3_prepare_v2]))
+AC_CHECK_LIB(sqlite3, sqlite3_open_v2,
+             AC_DEFINE(HAVE_SQLITE3_OPEN_V2, 1, [Define if the sqlite3 library has sqlite3_open_v2]))
+AC_CHECK_LIB(sqlite3, sqlite3_close_v2,
+             AC_DEFINE(HAVE_SQLITE3_CLOSE_V2, 1, [Define if the sqlite3 library has sqlite3_close_v2]))
+
 # Check for --with-tcltk-includes=path and --with-tcltk-libs=path
 AC_SUBST(TCLTK_INCLUDES)
 AC_SUBST(TCLTK_LIBS)
diff -r 14cb17682831 pyconfig.h.in
--- a/pyconfig.h.in	Tue Apr 26 11:47:10 2016 +0000
+++ b/pyconfig.h.in	Sat Apr 30 13:16:16 2016 +0300
@@ -873,6 +873,15 @@
 /* Define to 1 if you have the <spawn.h> header file. */
 #undef HAVE_SPAWN_H
 
+/* Define if the sqlite3 library has sqlite3_close_v2 */
+#undef HAVE_SQLITE3_CLOSE_V2
+
+/* Define if the sqlite3 library has sqlite3_open_v2 */
+#undef HAVE_SQLITE3_OPEN_V2
+
+/* Define if the sqlite3 library has sqlite3_prepare_v2 */
+#undef HAVE_SQLITE3_PREPARE_V2
+
 /* Define if your compiler provides ssize_t */
 #undef HAVE_SSIZE_T