diff --git a/PC/bdist_wininst/bdist_wininst.vcxproj b/PC/bdist_wininst/bdist_wininst.vcxproj
--- a/PC/bdist_wininst/bdist_wininst.vcxproj
+++ b/PC/bdist_wininst/bdist_wininst.vcxproj
@@ -65,16 +65,20 @@
   <ItemDefinitionGroup>
     <Midl>
       <TypeLibraryName>$(OutDir)wininst.tlb</TypeLibraryName>
     </Midl>
     <ClCompile>
       <Optimization>MinSpace</Optimization>
       <AdditionalIncludeDirectories>$(PySourcePath)Modules\zlib;%(AdditionalIncludeDirectories)</AdditionalIncludeDirectories>
       <PreprocessorDefinitions>_CRT_SECURE_NO_DEPRECATE;_CRT_NONSTDC_NO_DEPRECATE;%(PreprocessorDefinitions)</PreprocessorDefinitions>
+      <RuntimeLibrary Condition="'$(Configuration)|$(Platform)'=='Release|Win32'">MultiThreaded</RuntimeLibrary>
+      <RuntimeLibrary Condition="'$(Configuration)|$(Platform)'=='Debug|Win32'">MultiThreadedDebug</RuntimeLibrary>
+      <RuntimeLibrary Condition="'$(Configuration)|$(Platform)'=='Debug|x64'">MultiThreadedDebug</RuntimeLibrary>
+      <RuntimeLibrary Condition="'$(Configuration)|$(Platform)'=='Release|x64'">MultiThreaded</RuntimeLibrary>
     </ClCompile>
     <ResourceCompile>
       <AdditionalIncludeDirectories>$(PySourcePath)PC\bdist_wininst;%(AdditionalIncludeDirectories)</AdditionalIncludeDirectories>
     </ResourceCompile>
     <Link>
       <AdditionalDependencies>comctl32.lib;imagehlp.lib;%(AdditionalDependencies)</AdditionalDependencies>
     </Link>
   </ItemDefinitionGroup>
diff --git a/PC/bdist_wininst/install.c b/PC/bdist_wininst/install.c
--- a/PC/bdist_wininst/install.c
+++ b/PC/bdist_wininst/install.c
@@ -148,16 +148,23 @@ BOOL pyc_compile, pyo_compile;
 HKEY hkey_root = (HKEY)-1;
 
 BOOL success;                   /* Installation successful? */
 char *failure_reason = NULL;
 
 HANDLE hBitmap;
 char *bitmap_bytes;
 
+static const char *REGISTRY_SUFFIX_6432 =
+#ifdef MS_WIN64
+                                          "";
+#else
+                                          "-32";
+#endif
+
 
 #define WM_NUMFILES WM_USER+1
 /* wParam: 0, lParam: total number of files */
 #define WM_NEXTFILE WM_USER+2
 /* wParam: number of this file */
 /* lParam: points to pathname */
 
 static BOOL notify(int code, char *fmt, ...);
@@ -652,23 +659,27 @@ static HINSTANCE LoadPythonDll(char *fna
 
     /* make sure PYTHONHOME is set, to that sys.path is initialized correctly */
     wsprintf(buffer, "PYTHONHOME=%s", python_dir);
     _putenv(buffer);
     h = LoadLibrary(fname);
     if (h)
         return h;
     wsprintf(subkey_name,
-             "SOFTWARE\\Python\\PythonCore\\%d.%d\\InstallPath",
-             py_major, py_minor);
+             "SOFTWARE\\Python\\PythonCore\\%d.%d%s\\InstallPath",
+             py_major, py_minor, REGISTRY_SUFFIX_6432);
     if (ERROR_SUCCESS != RegQueryValue(HKEY_CURRENT_USER, subkey_name,
                                        fullpath, &size) &&
         ERROR_SUCCESS != RegQueryValue(HKEY_LOCAL_MACHINE, subkey_name,
                                        fullpath, &size))
         return NULL;
+    // The crt assembly is probably in the root of the install dir, so change
+    // to that directory before loading Python.
+    SetCurrentDirectory(fullpath);
+    // Tack on the DLL name and load it.
     strcat(fullpath, "\\");
     strcat(fullpath, fname);
     return LoadLibrary(fullpath);
 }
 
 static int prepare_script_environment(HINSTANCE hPython)
 {
     PyObject *mod;
@@ -2245,16 +2256,18 @@ int DoInstall(void)
 
     GetPrivateProfileString("Setup", "install_script", "",
                              install_script, sizeof(install_script),
                              ini_file);
 
     GetPrivateProfileString("Setup", "user_access_control", "",
                              user_access_control, sizeof(user_access_control), ini_file);
 
+    strcat(target_version, REGISTRY_SUFFIX_6432);
+
     // See if we need to do the Vista UAC magic.
     if (strcmp(user_access_control, "force")==0) {
         if (!MyIsUserAnAdmin()) {
             SpawnUAC();
             return 0;
         }
         // already admin - keep going
     } else if (strcmp(user_access_control, "auto")==0) {