import types

def patch_code(func, remove_const):
    co = func.__code__
    new_consts = tuple(const for const in co.co_consts if const != remove_const)
    code2 = types.CodeType(
        co.co_argcount,
        co.co_kwonlyargcount,
        co.co_nlocals,
        co.co_stacksize,
        co.co_flags,
        co.co_code,
        new_consts,
        co.co_names,
        co.co_varnames,
        co.co_filename,
        co.co_name,
        co.co_firstlineno,
        co.co_lnotab,
        co.co_freevars,
        co.co_cellvars)
    func.__code__ = code2

#f1, f2 = lambda: 1, lambda: 1.0
f1, f2 = lambda x: x in {1}, lambda x: x in {1.0}

types.CodeType
patch_code(f1, 1)
patch_code(f2, 1.0)

print("code is", f1.__code__ is f2.__code__)
print("code ==", f1.__code__ == f2.__code__)
print("consts", f1.__code__.co_consts, f2.__code__.co_consts)
print("consts ==", f1.__code__.co_consts == f2.__code__.co_consts)