import timeit

setup = 'x = 20000'

stmts = '''
# Loop with a high-proportion of opcodes with an oparg
while x:
    a, b, c, d, e, f, g = x, x, x, x, x, x, x
    x -= 1
'''

print(min(timeit.Timer(stmts, setup).repeat(7, 10000000)))