diff --git a/Python/ceval.c b/Python/ceval.c
--- a/Python/ceval.c
+++ b/Python/ceval.c
@@ -996,8 +996,13 @@
 
 #define INSTR_OFFSET()  ((int)(next_instr - first_instr))
 #define NEXTOP()        (*next_instr++)
+#if PY_LITTLE_ENDIAN
+#define NEXTARG()       (next_instr += 2, (int)(*((unsigned short *)(next_instr - 2))))
+#define PEEKARG()       ((int)(*((unsigned short *)(next_instr + 1))))
+#else
 #define NEXTARG()       (next_instr += 2, (next_instr[-1]<<8) + next_instr[-2])
 #define PEEKARG()       ((next_instr[2]<<8) + next_instr[1])
+#endif
 #define JUMPTO(x)       (next_instr = first_instr + (x))
 #define JUMPBY(x)       (next_instr += (x))