diff -r 0eeb39fc8ff5 Lib/test/test_winreg.py
--- a/Lib/test/test_winreg.py	Tue Dec 01 19:59:53 2015 +1100
+++ b/Lib/test/test_winreg.py	Wed Dec 02 20:04:56 2015 -0600
@@ -56,7 +56,7 @@
 
     def delete_tree(self, root, subkey):
         try:
-            hkey = OpenKey(root, subkey, KEY_ALL_ACCESS)
+            hkey = OpenKey(root, subkey, 0, KEY_ALL_ACCESS)
         except OSError:
             # subkey does not exist
             return
@@ -367,6 +367,18 @@
         finally:
             DeleteKey(HKEY_CURRENT_USER, test_key_name)
 
+    def test_read_string_containing_null(self):
+        # Test for issue 25778: REG_SZ should not contain null characters
+        try:
+            with CreateKey(HKEY_CURRENT_USER, test_key_name) as ck:
+                self.assertNotEqual(ck.handle, 0)
+                test_val = "A string\x00 with a null"
+                SetValueEx(ck, "test_name", 0, REG_SZ, test_val)
+                ret_val, ret_type = QueryValueEx(ck, "test_name")
+                self.assertEqual(ret_type, REG_SZ)
+                self.assertEqual(ret_val, "A string")
+        finally:
+            DeleteKey(HKEY_CURRENT_USER, test_key_name)
 
 
 @unittest.skipUnless(REMOTE_NAME, "Skipping remote registry tests")
diff -r 0eeb39fc8ff5 PC/winreg.c
--- a/PC/winreg.c	Tue Dec 01 19:59:53 2015 +1100
+++ b/PC/winreg.c	Wed Dec 02 20:04:56 2015 -0600
@@ -697,12 +697,8 @@
             {
                 /* the buffer may or may not have a trailing NULL */
                 wchar_t *data = (wchar_t *)retDataBuf;
-                int len = retDataSize / 2;
-                if (retDataSize && data[len-1] == '\0')
-                    retDataSize -= 2;
-                if (retDataSize <= 0)
-                    data = L"";
-                obData = PyUnicode_FromWideChar(data, retDataSize/2);
+                size_t len = wcsnlen(data, retDataSize / sizeof(wchar_t));
+                obData = PyUnicode_FromWideChar(data, len);
                 break;
             }
         case REG_MULTI_SZ: