diff -r d70026504feb Lib/ctypes/test/test_pointers.py
--- a/Lib/ctypes/test/test_pointers.py	Sat Nov 07 18:06:24 2015 +0200
+++ b/Lib/ctypes/test/test_pointers.py	Sat Nov 07 22:12:37 2015 +0200
@@ -195,9 +195,19 @@ class PointersTestCase(unittest.TestCase
         LargeNamedType = type('T' * 2 ** 25, (Structure,), {})
         self.assertTrue(POINTER(LargeNamedType))
 
+        # to not leak references, we must clean _pointer_type_cache
+        from ctypes import _pointer_type_cache
+        del _pointer_type_cache[LargeNamedType]
+
     def test_pointer_type_str_name(self):
         large_string = 'T' * 2 ** 25
-        self.assertTrue(POINTER(large_string))
+        P = POINTER(large_string)
+        self.assertTrue(P)
+
+        # to not leak references, we must clean _pointer_type_cache
+        from ctypes import _pointer_type_cache
+        del _pointer_type_cache[id(P)]
+
 
 if __name__ == '__main__':
     unittest.main()
diff -r d70026504feb Lib/ctypes/test/test_win32.py
--- a/Lib/ctypes/test/test_win32.py	Sat Nov 07 18:06:24 2015 +0200
+++ b/Lib/ctypes/test/test_win32.py	Sat Nov 07 22:12:37 2015 +0200
@@ -135,5 +135,9 @@ class Structures(unittest.TestCase):
             self.assertEqual(ret.top, top.value)
             self.assertEqual(ret.bottom, bottom.value)
 
+        # to not leak references, we must clean _pointer_type_cache
+        from ctypes import _pointer_type_cache
+        del _pointer_type_cache[RECT]
+
 if __name__ == '__main__':
     unittest.main()